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Corona … The Pfizer vaccine may be less effective in obese people

Obesity increases the risk of death due to “Covid-19” virus by nearly 50%

Italian researchers discovered that obese people only produce about half the amount of antibodies in response to the second dose of the Corona vaccine, compared to people who are in good health.

In a report published by the British newspaper “The Guardian”, the writer Linda Geddes said that the data indicate that the effectiveness of the “Pfizer-BioNTech” vaccine may be weak in people who suffer from obesity. The study was conducted by researcher Aldo Vinot and colleagues.

Although it is too early to know the relationship of this to the effectiveness of the vaccine, it may mean that people with obesity need an additional booster dose to ensure that they have adequate protection from the Corona virus.

In fact, previous research indicated that obesity increases the risk of death from the “Covid-19” virus by nearly 50%, in addition to doubling the risk of admission to hospital by 113%.

The author stated that this may be attributed to the fact that people who suffer from obesity often suffer from other basic disease conditions, such as heart disease or type 2 diabetes, which increase the risk of infection with the Corona virus, but excess body fat can They also affect metabolism, such as insulin resistance and inflammation, which makes it difficult for the body to fight infections.

This chronic, low-grade inflammatory condition would also impair some immune responses, including those released by B and T cells that lead to a protective response after vaccination.

Researcher Aldo Vinot and colleagues evaluated the antibody response after vaccinating 248 health care workers with two doses of the Pfizer-BioNTech vaccine.

And after 7 days of receiving the second dose, 99.5% of them developed a response to antibodies, and this response was greater than that recorded in people who had recovered from the “Covid-19” virus. However, the response of overweight and obese people was poor.

“Since obesity is a major risk factor for morbidity and mortality in patients with Covid-19 virus, an effective vaccination program should be planned for this subgroup,” Vinot and colleagues wrote.

Although more studies are needed, these data may have important implications for the development of vaccination strategies against the “Covid-19” virus, especially for people who are obese.

In the event that these data are confirmed by other in-depth studies, giving obese people an additional dose of the vaccine or a higher dose, may be one of the options that should be evaluated for making this population immunity.

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