Home / news / Hydroxychloroquine, an antimalarial drug dubbed a “gift from God” by US President Donald Trump for its potential ability to fight the new coronavirus, was found to be no more effective than standard treatment in a small Chinese study

Hydroxychloroquine, an antimalarial drug dubbed a “gift from God” by US President Donald Trump for its potential ability to fight the new coronavirus, was found to be no more effective than standard treatment in a small Chinese study

Hydroxychloroquine, an antimalarial drug dubbed a “gift from God” by US President Donald Trump for its potential ability to fight the new coronavirus, was found to be no more effective than standard treatment in a small Chinese study

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35 comments

  1. French government will provide result in two weeks, they are testing on 800 patients.

  2. > But a similar number of patients were examined in a recent French study that found the same drug to be highly effective at fighting the infection, especially when taken in combination with the antibiotic azithromycin

    From the article. So which is it? Is it effective or not?

  3. “The sample size is considered too small to be statistically significant. ”

    ​

    That is the only sentence that matters.

    Only 27 people, only 7 days of treatment.

  4. Firstly, let me put out that I’m an Immunologist working with anti-cancer therapies at the University of British Columbia.

    Secondly, I have read the study, and the methodology is in no way “horrible”, and regular practice in clinical trials. The abstract itself states that sample size is small so further studies to HCQ have to be done to establish its efficacy. This is data is exactly why the FDA drug approval pipeline takes so long, and its beneficial for us to make sure we don’t give everyone a drug that doesn’t do anything, or even worse: causes detrimental side effects for low benefit.

    For those that are so against at least acknowledging any research data from China, please show me studies with a greater sample size with a different **statistically significant** conclusion.

    EDIT: This comment was made out as a reply initially, but I decided to put it as a main comment so more people could see. I would also like to add that it is very important to distinguish whether someone is disregarding an article based off scientific merit, or rather because of their political sentiment.

  5. Cherry picking one shitty study, while there are literally dozens of clinical studies being done using this very promising medications, is pretty shitty and misleading.

    [23 clinical trials currently in China](https://www.sciencedirect.com/science/article/pii/S0883944120303907)

    Of course, you don’t just eat a gallon of the stuff like a Tide Pod moron. This stuff is usually used in a very careful cocktail with other compounds.

  6. Standard treatment in China includes antiviral drugs, which are also not prescribed in many countries including the US and are more expensive. Read the actual paper.

  7. This studied exactly 15 people who were given the drug.

  8. Wow, didn’t expect that. Extremely misleading headline from OP. The same article said that a French study with close to the same number of patients found it to be highly effective. They just cherry picked the Chinese section to fit an agenda. Sick.’

  9. And other studies have found it to be effective. The lack of consensus is why it’s getting further testing. It was apparently used in the first SARS outbreak as well.

    Also should we really believe anything coming out of China right now?

  10. I’m not going to be trusting anything coming out of that country for awhile.

  11. And now people with Lupus or RA can’t get their meds because of all this.

  12. This is an absurd headline and shouldn’t even be posted. 30 people in the study of which only 15 received this treatment and all but two have recovered.

    This article is criminal and could literally kill people based on completely bogus information.

  13. Once again, the anti-Trump crowd are as bad as Trump himself.

    Fact is, various experts have said Hydroxychloroquine *might* be a drug that helps, but they aren’t certain yet. Some studies are promising, and while none are suggesting much difference in symptoms, it might be enough to help people survive.

    Simply dismissing everything Trump says “because it’s Trump” is as unhelpful and no different to him making massive sweeping statements.

  14. They were giving patients chloroquine in china, not hydroxychloroquine, so this is surprising. I’d like to see the actual paper, which the article doesn’t link to. HCQ has been used in Japan and SK also where death rates are extremely low in comparison to other countries. Pretty sure they’re using it extensively in Germany and Netherlands too. I know everyone *really* wants to believe that trump was wrong, but there is good evidence that the treatment is effective if started early enough.

  15. The bit about Trump in this title could have been completely left out and the news would still be pertinent. The Trump derangement syndrome in this sub is cancerous beyond recognition.

  16. “The sample size is considered too small to be statistically significant.

    But a similar number of patients were examined in a recent French study that found the same drug to be highly effective at fighting the infection, especially when taken in combination with the antibiotic azithromycin.”

  17. Trump didn’t “dub” it that, he said it “could be” a gift from God. Meaning, if it works – which we don’t know yet.

    Yellow Journalism.

  18. From the article: The sample size is considered too small to be statistically significant

  19. Why do y’all have to mention Trump in EVERYTHING!?!?!?!

  20. The media is a piece of shit.

  21. Jesus Christ. Stop making this about Trump. The drug isn’t effective. The world continues to burn.

  22. The good news is that my wife and millions of others depend on those drugs to treat their autoimmune disorders cannot get them because there is now a “toilet paperesque” rush/hoarding of them because that fucking moron doesn’t understand the magnitude of the risk posed by playing fast and loose with facts in a situation driven by this much fear. We are unable to refill it because it is unavailable and probably remain so after her supply runs out. looking forward to the life-threatening flair up that will follow.

  23. Have covid. Used it. Turned things around for me very quickly. It worked wonders for me.

  24. I am an assistant manager of pharmacy at a large academic hospital in VA. My job has been to prepare the hospital medication supply.

    We are lucky that we haven’t seen the surge that NY has but we are preparing for it.

    We have been watching g the data very closely. Nearly everything identified early has found to be a bust. As for hydroxychloroquine, I do t think any of us felt like the data was strong.

    I’m not ready to write this off quite yet. It is an extremely small study. Like most of medicine there is rarely one drug or action that has a huge ffect since Of 50 or 75%.

    Most drug effects are much more subtle. We need trials in many hundred or thousands to see statistical significance.

  25. And now we trust the Chinese government the same government that has been lying and spreading misinformation is that what we are rolling with cool

  26. Stopped reading after “small Chinese study” which pretty much means that the sample size is too small to make an informed opinion

  27. Trump has the audacity to be optimistic about a potential treatment? That piece of…/s

  28. Goddamn this site fucking hates trump to a fault.

  29. Chinese science magically gains rock-solid credibility when the results can be used to bash Trump.

  30. So you’re saying trust the chinese government over the other 3 studies with a 100% success rate? After they lied since January and caused this mess and screwed our whole economy along with much of the world? Blocked the CDC from helping? Made the WHO report this wasn’t transmittable through human to human contact? Really??? Try thinking it through.

  31. Didn’t China tell us it was effective earlier?

  32. I am very interested to see more studies and data about hydroxychloroquine, because it may or may not be an effective treatment, and the answer to that question will have a huge impact on the course of this pandemic.

    What I do not care about at all is if Trump is right or wrong. Why does every fucking article about hydroxychlorquine now have to reference Trump? If it works is he going to somehow get the credit? If it doesn’t is he a monster for saying it might be a good treatment when thousands of doctors and scientists are saying the same thing, and we are all looking at the same damn data?

  33. [A larger study](https://www.ncbi.nlm.nih.gov/pubmed/32074550) in China found that:

    “*Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People’s Republic of China for treatment of COVID-19 infection in larger populations in the future.* ”

    [A Group of Chinese experts](https://www.ncbi.nlm.nih.gov/pubmed/32164085) also “*recommended chloroquine phosphate tablet, 500mg twice per day for 10 days for patients diagnosed as mild, moderate and severe cases of novel coronavirus pneumonia and without contraindications to chloroquine.*”

    Hydrochloroquine is also a [recommended antiviral treatment](http://www.koreabiomed.com/news/articleView.html?idxno=7428) for old patients or patients with special vulnerabilities South Korea:

    >However, if patients are old or have underlying conditions with serious symptoms, physicians should consider an antiviral treatment. If they decide to use the antiviral therapy, they should start the administration as soon as possible, the task force noted.
    >
    >For the antiviral treatment, the doctors recommended lopinavir 400mg/ritonavir 100mg (Kaletra two tablets, twice a day) or chloroquine 500mg orally per day.
    >
    >As chloroquine is not available in Korea, doctors could consider hydroxychloroquine 400mg orally per day, they said. There is no evidence that using lopinavir/ritonavir with chloroquine is more effective than monotherapies, they added.

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